The high frequency vibrations of these sounds are analyzed and discussed. Two cases of idiopathic cardiomyopathy in children are described. Although classifiable respectively as of the non-obstructive or dilating type (in case 1) and of the restrictive type (in case 2), some peculiar clinical and angiocardiographic aspects could be found which differentiated them from the typical forms. In case 1 multiple semilunar dilatations were present at the posterobasal level of the left ventricle.
In case 2 the restriction of the ventricular chamber with markedly reduced compliance affected only the left ventricle, with marked dilatation of the left atrium and right side cavities. As occurs in the field of idiopathic cardiomyopathies, intermediate forms of anatomical variations can be found with clinical and angiographic atypical features.
The incidence of ventricular arrhythmias during muscular work in 400 patients hospitalized for clear or suspected coronary artery disease who underwent coronaroangiography and exercise test was studied. The correlations between the arrhythmias and some hemodynamic parameters and the coronaroangiogrphy patterns and left ventricle cineangiography were investigated.
In the present study, the ventricular arrhythmias during muscular work do not seem to be of diagnostic significance. Serum digoxin levels during maintenance therapy in children of four different age groups were determined by a radioimmunoassay technique. For each patient, three determinations, at the peak level, at the plateau and at the final phase, were done. The newborn group showed in all three phases serum digoxin levels significantly higher than those found in the other groups, in spite of an only slightly higher dosage of digoxin used in comparison to the other groups.
None of the factors that were supposed to be significant in the mechanism of the ventricular arrhythmias, such as high left ventricular end dyastolic pressure, modified myocardial contractility, previous myocardial infarct, or higher lesions of coronary arteries, gave significant correlations. Senescent rats were administered ethanol by gastric intubation at hourly intervals. After 1 h, there was a rapid increase in the specific activities of two isoenzymes of liver mitochondrial aldehyde dehydrogenase which was sustained for the next 2 h.No further changes were observed during the course of the following 2 h.
Protein intakes, energy intakes and serum albumin levels were measured in a long-stay geriatric unit. There was a significant positive correlation between albumin levels and protein intake in women, but not in men. A positive correlation was found between albumin levels and protein to calorie ratios in both men and women. This suggests that the protein intakes of long-stay geriatric patients may be suboptimal.
Regional cerebral blood flow and its autoregulation after intravenous glycerol infusion have been studied in eight patients in the acute phase of cerebral infarction. Glycerol seems to improve the cerebral blood flow in the damaged region but does not seem to restore autoregulation. We have examined 26 consecutive jaundiced patients referred to the ultrasound clinic. A differentiation between extrahepatic and other causes of jaundice was possible in 23 of the 24 patients satisfactorily examined. The use of ultrasonic techniques in the jaundiced patient offers a high degree of accuracy to the clinician, and little or no discomfort to the patient.
The transport of sodium and chloride across human jejunal and ileal mucosa was studied using an in vitro technique. Specimens of mucosa removed at operation were stripped of muscle coats, mounted in specially designed Perspex flux chambers and bathed in warmed oxygenated and stirred buffer solutions. Evidence was obtained for the active transport of sodium in both jejunum and ileum and of chloride in the ileum.
Sodium absorption was enhanced by glucose in both regions of the gut but net chloride transport was unaffected. Glucose had a greater effect on sodium transport in the ileum than the jejunum. The electrical potential difference and resistance was greater and undirectional ion fluxes smaller in jejunal than ileal mucosa. Many of these results with human intestine are similar to results reported with in vitro animal intestine. Apparent discrepancies between the behavior in vivo of human intestine and in vitro of animal intestine are thus likely to be due predominantly to technical rather species differences. Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance.